Cargando…

Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease

Infection of human skin with Mycobacterium ulcerans, the causative agent of Buruli ulcer, is associated with the systemic diffusion of a bacterial macrolide named mycolactone. Patients with progressive disease show alterations in their serum proteome, likely reflecting the inhibition of secreted pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Niang, Fatoumata, Sarfo, Fred S., Frimpong, Michael, Guenin-Macé, Laure, Wansbrough-Jones, Mark, Stinear, Timothy, Phillips, Richard O., Demangel, Caroline
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669498/ https://www.ncbi.nlm.nih.gov/pubmed/26634444 http://dx.doi.org/10.1038/srep17693

Ejemplares similares

Mycolactone Diffuses into the Peripheral Blood of Buruli Ulcer Patients - Implications for Diagnosis and Disease Monitoring
por: Sarfo, Fred S., et al.
Publicado: (2011)

Recent advances: role of mycolactone in the pathogenesis and monitoring of Mycobacterium ulcerans infection/Buruli ulcer disease
por: Sarfo, Fred Stephen, et al.
Publicado: (2015)

Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease
por: Phillips, Richard O., et al.
Publicado: (2014)

Mycolactone subverts immunity by selectively blocking the Sec61 translocon
por: Baron, Ludivine, et al.
Publicado: (2016)

Mycolactone displays anti-inflammatory effects on the nervous system
por: Isaac, Caroline, et al.
Publicado: (2017)

A Severe Case of Buruli Ulcer Disease with Pleural Effusions
por: Sarfo, Fred S., et al.
Publicado: (2014)

Molecular Mechanisms Underpinning the Circulation and Cellular Uptake of Mycobacterium ulcerans Toxin Mycolactone
por: Tello Rubio, Bruno, et al.
Publicado: (2021)

A Novel Mycolactone Toxin Obtained by Biosynthetic Engineering
por: Hong, Hui, et al.
Publicado: (2007)

Infection with Mansonella perstans Nematodes in Buruli Ulcer Patients, Ghana
por: Phillips, Richard O., et al.
Publicado: (2014)

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria
por: Hong, Hui, et al.
Publicado: (2008)

Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer
por: En, Junichiro, et al.
Publicado: (2017)

Genetic Diversity of PCR-Positive, Culture-Negative and Culture-Positive Mycobacterium ulcerans Isolated from Buruli Ulcer Patients in Ghana
por: Williamson, Heather, et al.
Publicado: (2014)

Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system
por: Colucci-Guyon, Emma, et al.
Publicado: (2020)

Mycolactone Gene Expression Is Controlled by Strong SigA-Like Promoters with Utility in Studies of Mycobacterium ulcerans and Buruli Ulcer
por: Tobias, Nicholas J., et al.
Publicado: (2009)

Mycobacterium ulcerans DNA Not Detected in Faecal Samples from Buruli Ulcer Patients: Results of a Pilot Study
por: Sarfo, Fred S., et al.
Publicado: (2011)

RNA Aptamer That Specifically Binds to Mycolactone and Serves as a Diagnostic Tool for Diagnosis of Buruli Ulcer
por: Sakyi, Samuel A., et al.
Publicado: (2016)

Infiltrating leukocytes surround early Buruli ulcer lesions, but are unable to reach the mycolactone producing mycobacteria
por: Ruf, Marie-Thérèse, et al.
Publicado: (2017)

What about Current Diversity of Mycolactone-Producing Mycobacteria? Implication for the Diagnosis and Treatment of Buruli Ulcer
por: Combe, Marine, et al.
Publicado: (2023)

Buruli Ulcer in Liberia, 2012
por: Kollie, Karsor, et al.
Publicado: (2014)

Detection of Mycolactone A/B in Mycobacterium ulcerans–Infected Human Tissue
por: Sarfo, Fred Stephen, et al.
Publicado: (2010)

Correction: Mycolactone Gene Expression Is Controlled by Strong SigA-Like Promoters with Utility in Studies of Mycobacterium ulcerans and Buruli Ulcer
por: Tobias, Nicholas J., et al.
Publicado: (2010)

IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection
por: Loglo, Aloysius D., et al.
Publicado: (2018)

Kinetics of mycolactone in human subcutaneous tissue during antibiotic therapy for Mycobacterium ulcerans disease
por: Sarfo, Fred S, et al.
Publicado: (2014)

Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions
por: Ogbechi, Joy, et al.
Publicado: (2015)

From Bacterial Toxin to Therapeutic Agent: The Unexpected Fate of Mycolactone
por: Ricci, Daniela, et al.
Publicado: (2023)

Co-infection of HIV in patients with Buruli ulcer disease in Central Ghana
por: Amoako, Yaw Ampem, et al.
Publicado: (2021)

Distribution and Risk of Mycolactone-Producing Mycobacteria Transmission within Buruli Ulcer Endemic Communities in Côte d’Ivoire
por: Dassi, Christelle, et al.
Publicado: (2017)

Clearance of viable Mycobacterium ulcerans from Buruli ulcer lesions during antibiotic treatment as determined by combined 16S rRNA reverse transcriptase /IS 2404 qPCR assay
por: Sarpong-Duah, Mabel, et al.
Publicado: (2017)

Recombinant Antibodies against Mycolactone
por: Naranjo, Leslie, et al.
Publicado: (2019)

Cellular Immunity Confers Transient Protection in Experimental Buruli Ulcer following BCG or Mycolactone-Negative Mycobacterium ulcerans Vaccination
por: Fraga, Alexandra G., et al.
Publicado: (2012)

Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology
por: Foulon, M., et al.
Publicado: (2020)

Mycolactone induces cell death by SETD1B-dependent degradation of glutathione
por: Förster, Birgit, et al.
Publicado: (2020)

Paradoxical reactions in Buruli ulcer after initiation of antibiotic therapy: Relationship to bacterial load
por: Frimpong, Michael, et al.
Publicado: (2019)

Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons: Mechanisms underlying hypoalgesia in Buruli ulcer
por: Anand, U, et al.
Publicado: (2016)

Molecular Characterization of Mycolactone Producing Mycobacteria from Aquatic Environments in Buruli Ulcer Non-Endemic Areas in Côte d’Ivoire
por: Tano, Marcellin B., et al.
Publicado: (2017)

The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer
por: Hall, Belinda S., et al.
Publicado: (2022)

Alternative boronic acids in the detection of Mycolactone A/B using the thin layer chromatography (f-TLC) method for diagnosis of Buruli ulcer
por: Akolgo, Gideon A., et al.
Publicado: (2023)

Barriers to Buruli ulcer treatment completion in the Ashanti and Central Regions, Ghana
por: Collinson, Shelui, et al.
Publicado: (2020)

The Cell Wall-Associated Mycolactone Polyketide Synthases Are Necessary but Not Sufficient for Mycolactone Biosynthesis
por: Porter, Jessica L., et al.
Publicado: (2013)

On the origin of Mycobacterium ulcerans, the causative agent of Buruli ulcer
por: Doig, Kenneth D, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_22n9holl7sarjto8mnb1e59tn6