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An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor
BACKGROUND: Warthin tumors presenting concomitantly with a lymphoma is vanishingly rare with only 15 reported cases in English literature. Herein, we report an unusual initial presentation of a mantle cell lymphoma involving the lymphoid stroma of a Warthin tumor. CASE PRESENTATION: A seventy-seven...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669604/ https://www.ncbi.nlm.nih.gov/pubmed/26634829 http://dx.doi.org/10.1186/s13000-015-0444-4 |
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author | Arcega, Ramir S. Feinstein, Aaron J. Bhuta, Sunita Blackwell, Keith E. Rao, Nagesh P. Pullarkat, Sheeja T. |
author_facet | Arcega, Ramir S. Feinstein, Aaron J. Bhuta, Sunita Blackwell, Keith E. Rao, Nagesh P. Pullarkat, Sheeja T. |
author_sort | Arcega, Ramir S. |
collection | PubMed |
description | BACKGROUND: Warthin tumors presenting concomitantly with a lymphoma is vanishingly rare with only 15 reported cases in English literature. Herein, we report an unusual initial presentation of a mantle cell lymphoma involving the lymphoid stroma of a Warthin tumor. CASE PRESENTATION: A seventy-seven year old otherwise healthy gentleman with a 50-pack year smoking history presents with a slowly enlarging left cheek mass. CT scan of the neck demonstrated a left parotid gland tumor measuring 3.4 cm in greatest dimension. He underwent a left superficial parotidectomy, with subsequent histopathologic examination revealing a Warthin tumor with extensive expansion of the lymphoid stroma. Flow cytometric, immunohistochemical, and cytogenetic studies of the stromal component of the tumor confirmed the presence of a mantle cell lymphoma. Clinical staging demonstrated stage IVa disease, and was considered to be at low to intermediate risk due to the slow growth of the parotid lesion. The patient is undergoing close follow up with repeat PET-CT scans at six months. CONCLUSION: To the best of our knowledge, this is the first well documented collision tumor between mantle cell lymphoma and a Warthin tumor. This case also brings to light the significance of thorough evaluation of the lymphoid component of Warthin tumor. |
format | Online Article Text |
id | pubmed-4669604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-46696042015-12-05 An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor Arcega, Ramir S. Feinstein, Aaron J. Bhuta, Sunita Blackwell, Keith E. Rao, Nagesh P. Pullarkat, Sheeja T. Diagn Pathol Case Report BACKGROUND: Warthin tumors presenting concomitantly with a lymphoma is vanishingly rare with only 15 reported cases in English literature. Herein, we report an unusual initial presentation of a mantle cell lymphoma involving the lymphoid stroma of a Warthin tumor. CASE PRESENTATION: A seventy-seven year old otherwise healthy gentleman with a 50-pack year smoking history presents with a slowly enlarging left cheek mass. CT scan of the neck demonstrated a left parotid gland tumor measuring 3.4 cm in greatest dimension. He underwent a left superficial parotidectomy, with subsequent histopathologic examination revealing a Warthin tumor with extensive expansion of the lymphoid stroma. Flow cytometric, immunohistochemical, and cytogenetic studies of the stromal component of the tumor confirmed the presence of a mantle cell lymphoma. Clinical staging demonstrated stage IVa disease, and was considered to be at low to intermediate risk due to the slow growth of the parotid lesion. The patient is undergoing close follow up with repeat PET-CT scans at six months. CONCLUSION: To the best of our knowledge, this is the first well documented collision tumor between mantle cell lymphoma and a Warthin tumor. This case also brings to light the significance of thorough evaluation of the lymphoid component of Warthin tumor. BioMed Central 2015-12-03 /pmc/articles/PMC4669604/ /pubmed/26634829 http://dx.doi.org/10.1186/s13000-015-0444-4 Text en © Arcega et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Arcega, Ramir S. Feinstein, Aaron J. Bhuta, Sunita Blackwell, Keith E. Rao, Nagesh P. Pullarkat, Sheeja T. An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor |
title | An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor |
title_full | An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor |
title_fullStr | An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor |
title_full_unstemmed | An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor |
title_short | An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor |
title_sort | unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669604/ https://www.ncbi.nlm.nih.gov/pubmed/26634829 http://dx.doi.org/10.1186/s13000-015-0444-4 |
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