Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma

BACKGROUND: An inverse correlation between expression of the aldehyde dehydrogenase 1 subfamily A2 (ALDH1A2) and gene promoter methylation has been identified as a common feature of oropharyngeal squamous cell carcinoma (OPSCC). Moreover, low ALDH1A2 expression was associated with an unfavorable pro...

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Detalles Bibliográficos
Autores principales: Seidensaal, Katharina, Nollert, Andre, Feige, Agnes Hiou, Muller, Marie, Fleming, Thomas, Gunkel, Nikolas, Zaoui, Karim, Grabe, Niels, Weichert, Wilko, Weber, Klaus-Josef, Plinkert, Peter, Simon, Christian, Hess, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669670/
https://www.ncbi.nlm.nih.gov/pubmed/26634247
http://dx.doi.org/10.1186/s12943-015-0476-0

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