PD-1 and Tim-3 pathways are associated with regulatory CD8(+) T-cell function in decidua and maintenance of normal pregnancy

CD8(+) T cells are critical in the balance between fetal tolerance and antiviral immunity. T-cell immunoglobulin mucin-3 (Tim-3) and programmed cell death-1 (PD-1) are important negative immune regulatory molecules involved in viral persistence and tumor metastasis. Here, we demonstrate that Tim-3(+...

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Detalles Bibliográficos
Autores principales: Wang, S-C, Li, Y-H, Piao, H-L, Hong, X-W, Zhang, D, Xu, Y-Y, Tao, Y, Wang, Y, Yuan, M-M, Li, D-J, Du, M-R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669692/
https://www.ncbi.nlm.nih.gov/pubmed/25950468
http://dx.doi.org/10.1038/cddis.2015.112

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