PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model

Brain thiamine homeostasis has an important role in energy metabolism and displays reduced activity in Alzheimer's disease (AD). Thiamine deficiency (TD) induces regionally specific neuronal death in the animal and human brains associated with a mild chronic impairment of oxidative metabolism....

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Detalles Bibliográficos
Autores principales: Mouton-Liger, F, Rebillat, A-S, Gourmaud, S, Paquet, C, Leguen, A, Dumurgier, J, Bernadelli, P, Taupin, V, Pradier, L, Rooney, T, Hugon, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669750/
https://www.ncbi.nlm.nih.gov/pubmed/25590804
http://dx.doi.org/10.1038/cddis.2014.552

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