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NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone

Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors (e.g., FK866) target the most active pathway of NAD(+) synthesis in tumor cells, but lack tumor-selectivity for use as a single agent. Reducing NAD(+) pools by inhibiting NAMPT primed pancreatic ductal adenocarcinoma (PDA) cells for poly(ADP...

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Detalles Bibliográficos
Autores principales:	Moore, Z, Chakrabarti, G, Luo, X, Ali, A, Hu, Z, Fattah, F J, Vemireddy, R, DeBerardinis, R J, Brekken, R A, Boothman, D A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669762/ https://www.ncbi.nlm.nih.gov/pubmed/25590809 http://dx.doi.org/10.1038/cddis.2014.564

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