PINK1-induced mitophagy promotes neuroprotection in Huntington's disease

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by aberrant expansion of CAG repeat in the huntingtin gene. Mutant Huntingtin (mHtt) alters multiple cellular processes, leading to neuronal dysfunction and death. Among those alterations, impaired mitochondrial metabolism s...

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Detalles Bibliográficos
Autores principales: Khalil, B, El Fissi, N, Aouane, A, Cabirol-Pol, M-J, Rival, T, Liévens, J-C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669776/
https://www.ncbi.nlm.nih.gov/pubmed/25611391
http://dx.doi.org/10.1038/cddis.2014.581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669776/
https://www.ncbi.nlm.nih.gov/pubmed/25611391
http://dx.doi.org/10.1038/cddis.2014.581

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