F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7

Fbxl7, a subunit of the SCF (Skp-Cul1-F-box protein) complex induces mitotic arrest in cells; however, molecular factors that control its cellular abundance remain largely unknown. Here, we identified that an orphan F-box protein, Fbxl18, targets Fbxl7 for its polyubiquitylation and proteasomal degr...

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Detalles Bibliográficos
Autores principales: Liu, Y, Lear, T, Zhao, Y, Zhao, J, Zou, C, Chen, B B, Mallampalli, R K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669792/
https://www.ncbi.nlm.nih.gov/pubmed/25654763
http://dx.doi.org/10.1038/cddis.2014.585

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