Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny

Mitochondrial DNA (mtDNA) copy number is strictly regulated during differentiation so that cells with a high requirement for ATP generated through oxidative phosphorylation have high mtDNA copy number, whereas those with a low requirement have few copies. Using immunoprecipitation of DNA methylation...

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Detalles Bibliográficos
Autores principales: Lee, W, Johnson, J, Gough, D J, Donoghue, J, Cagnone, G L M, Vaghjiani, V, Brown, K A, Johns, T G, St. John, J C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669800/
https://www.ncbi.nlm.nih.gov/pubmed/25719248
http://dx.doi.org/10.1038/cddis.2015.34

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