p21-activated kinase 1 determines stem-like phenotype and sunitinib resistance via NF-κB/IL-6 activation in renal cell carcinoma

The p21-activated kinase 1 (PAK1), a serine/threonine kinase that orchestrates cytoskeletal remodeling and cell motility, has been shown to function as downstream node for various oncogenic signaling pathways to promote cell proliferation, regulate apoptosis and accelerate mitotic abnormalities, res...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Y, Liu, H, Xu, L, An, H, Liu, W, Liu, Y, Lin, Z, Xu, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669810/
https://www.ncbi.nlm.nih.gov/pubmed/25675297
http://dx.doi.org/10.1038/cddis.2015.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669810/
https://www.ncbi.nlm.nih.gov/pubmed/25675297
http://dx.doi.org/10.1038/cddis.2015.2

Ejemplares similares