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Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathways

Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel that is sensitive to cell swelling, arachidonic acid and its metabolites, epoxyeicosatrienoic acids, which are associated with cerebral ischemia. The activation of TRPV4 induces cytotoxicity in many types of cells...

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Detalles Bibliográficos
Autores principales:	Jie, P, Hong, Z, Tian, Y, Li, Y, Lin, L, Zhou, L, Du, Y, Chen, L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669828/ https://www.ncbi.nlm.nih.gov/pubmed/26043075 http://dx.doi.org/10.1038/cddis.2015.146

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