Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant

Growing evidence suggests the Δ133p53α isoform may function as an oncogene. It is overexpressed in many tumors, stimulates pathways involved in tumor progression, and inhibits some activities of wild-type p53, including transactivation and apoptosis. We hypothesized that Δ133p53α would have an even...

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Detalles Bibliográficos
Autores principales: Slatter, T L, Hung, N, Bowie, S, Campbell, H, Rubio, C, Speidel, D, Wilson, M, Baird, M, Royds, J A, Braithwaite, A W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669831/
https://www.ncbi.nlm.nih.gov/pubmed/26068791
http://dx.doi.org/10.1038/cddis.2015.149

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