Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss

Synaptic loss is one of the major features of Alzheimer's disease (AD) and correlates with the degree of dementia. N-methyl-d-aspartate receptors (NMDARs) have been shown to mediate downstream effects of the β-amyloid peptide (Aβ) in AD models. NMDARs can trigger intracellular cascades via Ca(2...

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Detalles Bibliográficos
Autores principales: Birnbaum, J H, Bali, J, Rajendran, L, Nitsch, R M, Tackenberg, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669839/
https://www.ncbi.nlm.nih.gov/pubmed/26086964
http://dx.doi.org/10.1038/cddis.2015.160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669839/
https://www.ncbi.nlm.nih.gov/pubmed/26086964
http://dx.doi.org/10.1038/cddis.2015.160

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