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Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss
Synaptic loss is one of the major features of Alzheimer's disease (AD) and correlates with the degree of dementia. N-methyl-d-aspartate receptors (NMDARs) have been shown to mediate downstream effects of the β-amyloid peptide (Aβ) in AD models. NMDARs can trigger intracellular cascades via Ca(2...
Autores principales: | Birnbaum, J H, Bali, J, Rajendran, L, Nitsch, R M, Tackenberg, C |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669839/ https://www.ncbi.nlm.nih.gov/pubmed/26086964 http://dx.doi.org/10.1038/cddis.2015.160 |
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