Cargando…
Seroprevalence of infectious markers & their trends in blood donors in a hospital based blood bank in north india
BACKGROUND & OBJECTIVES: Hepatitis B virus (HBV), human immunodeficiency virus (HIV), hepatitis C virus (HCV) and syphilis infections pose a great threat to blood safety. This study was undertaken to investigate the seroprevalence of serologic markers for transfusion transmitted infections (TTIs...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669867/ https://www.ncbi.nlm.nih.gov/pubmed/26458348 http://dx.doi.org/10.4103/0971-5916.166598 |
_version_ | 1782404183073226752 |
---|---|
author | Makroo, R.N. Hegde, Vikas Chowdhry, Mohit Bhatia, Aakanksha Rosamma, N.L. |
author_facet | Makroo, R.N. Hegde, Vikas Chowdhry, Mohit Bhatia, Aakanksha Rosamma, N.L. |
author_sort | Makroo, R.N. |
collection | PubMed |
description | BACKGROUND & OBJECTIVES: Hepatitis B virus (HBV), human immunodeficiency virus (HIV), hepatitis C virus (HCV) and syphilis infections pose a great threat to blood safety. This study was undertaken to investigate the seroprevalence of serologic markers for transfusion transmitted infections (TTIs) among blood donors at a hospital based blood centre in north India over a period of nine years. METHODS: The results of serologic markers for TTIs (HBsAg, anti-HCV, anti-HIV and syphilis) of all blood donations (both voluntary and replacement) at our hospital from January 2005 to December 2013 were screened. Additional analysis was conducted to examine the prevalence trends associated with each of the positive marker. RESULTS: The data of 180,477 donors [173,019 (95.86%) males and 7,458 (4.13%) females] were analyzed. Replacement donations [174,939 (96.93%)] represented the majority whereas, only 5,538 (3.06%) donations were from the voluntary donors. The risk of blood being reactive was three times higher in male donors when compared with the female donors. The risk of blood being reactive for one or more infectious markers was 2.1 times higher in replacement donors when compared with the voluntary donors. Seropositivity of HIV, HBsAg, HBcAb, syphilis showed a significant decreasing trend (P<0.05) while there was an increasing trend in HCV infection which was insignificant. INTERPRETATION & CONCLUSIONS: This study reflects that the risk of TTIs has been decreased over time with respect to HIV, HBV and syphilis, but the trends for HCV remains almost the same in blood donors. Blood transfusion remains a risk factor for the spread of blood-borne infections. Therefore, improvements are needed to strengthen both safety and availability of blood. |
format | Online Article Text |
id | pubmed-4669867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-46698672015-12-17 Seroprevalence of infectious markers & their trends in blood donors in a hospital based blood bank in north india Makroo, R.N. Hegde, Vikas Chowdhry, Mohit Bhatia, Aakanksha Rosamma, N.L. Indian J Med Res Original Article BACKGROUND & OBJECTIVES: Hepatitis B virus (HBV), human immunodeficiency virus (HIV), hepatitis C virus (HCV) and syphilis infections pose a great threat to blood safety. This study was undertaken to investigate the seroprevalence of serologic markers for transfusion transmitted infections (TTIs) among blood donors at a hospital based blood centre in north India over a period of nine years. METHODS: The results of serologic markers for TTIs (HBsAg, anti-HCV, anti-HIV and syphilis) of all blood donations (both voluntary and replacement) at our hospital from January 2005 to December 2013 were screened. Additional analysis was conducted to examine the prevalence trends associated with each of the positive marker. RESULTS: The data of 180,477 donors [173,019 (95.86%) males and 7,458 (4.13%) females] were analyzed. Replacement donations [174,939 (96.93%)] represented the majority whereas, only 5,538 (3.06%) donations were from the voluntary donors. The risk of blood being reactive was three times higher in male donors when compared with the female donors. The risk of blood being reactive for one or more infectious markers was 2.1 times higher in replacement donors when compared with the voluntary donors. Seropositivity of HIV, HBsAg, HBcAb, syphilis showed a significant decreasing trend (P<0.05) while there was an increasing trend in HCV infection which was insignificant. INTERPRETATION & CONCLUSIONS: This study reflects that the risk of TTIs has been decreased over time with respect to HIV, HBV and syphilis, but the trends for HCV remains almost the same in blood donors. Blood transfusion remains a risk factor for the spread of blood-borne infections. Therefore, improvements are needed to strengthen both safety and availability of blood. Medknow Publications & Media Pvt Ltd 2015-09 /pmc/articles/PMC4669867/ /pubmed/26458348 http://dx.doi.org/10.4103/0971-5916.166598 Text en Copyright: © Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Makroo, R.N. Hegde, Vikas Chowdhry, Mohit Bhatia, Aakanksha Rosamma, N.L. Seroprevalence of infectious markers & their trends in blood donors in a hospital based blood bank in north india |
title | Seroprevalence of infectious markers & their trends in blood donors in a hospital based blood bank in north india |
title_full | Seroprevalence of infectious markers & their trends in blood donors in a hospital based blood bank in north india |
title_fullStr | Seroprevalence of infectious markers & their trends in blood donors in a hospital based blood bank in north india |
title_full_unstemmed | Seroprevalence of infectious markers & their trends in blood donors in a hospital based blood bank in north india |
title_short | Seroprevalence of infectious markers & their trends in blood donors in a hospital based blood bank in north india |
title_sort | seroprevalence of infectious markers & their trends in blood donors in a hospital based blood bank in north india |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669867/ https://www.ncbi.nlm.nih.gov/pubmed/26458348 http://dx.doi.org/10.4103/0971-5916.166598 |
work_keys_str_mv | AT makroorn seroprevalenceofinfectiousmarkerstheirtrendsinblooddonorsinahospitalbasedbloodbankinnorthindia AT hegdevikas seroprevalenceofinfectiousmarkerstheirtrendsinblooddonorsinahospitalbasedbloodbankinnorthindia AT chowdhrymohit seroprevalenceofinfectiousmarkerstheirtrendsinblooddonorsinahospitalbasedbloodbankinnorthindia AT bhatiaaakanksha seroprevalenceofinfectiousmarkerstheirtrendsinblooddonorsinahospitalbasedbloodbankinnorthindia AT rosammanl seroprevalenceofinfectiousmarkerstheirtrendsinblooddonorsinahospitalbasedbloodbankinnorthindia |