Short-Term Circadian Disruption Impairs Bile Acid and Lipid Homeostasis in Mice

BACKGROUND & AIMS: Bile acids are physiologic detergents that also activate nuclear receptors to regulate glucose and lipid homeostasis. Cholesterol 7α-hydroxylase (Cyp7a1), the rate-limiting enzyme that converts cholesterol to bile acids, is transcriptionally regulated by bile acids and circadi...

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Detalles Bibliográficos
Autores principales: Ferrell, Jessica M., Chiang, John Y.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669895/
https://www.ncbi.nlm.nih.gov/pubmed/26645046
http://dx.doi.org/10.1016/j.jcmgh.2015.08.003

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