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The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA

The roles of GABAergic receptors of the Basolateral amygdala (BLA) in the cannabinoid CB1 receptor agonist (arachydonilcyclopropylamide; ACPA)-induced anxiolytic-like effect and aversive memory deficit in adult male mice were examined in elevated plus-maze task. Results showed that pre-test intra-pe...

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Autores principales: Kangarlu-Haghighi, Katayoon, Oryan, Shahrbanoo, Nasehi, Mohammad, Zarrindast, Mohammad-Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669909/
https://www.ncbi.nlm.nih.gov/pubmed/26648818
http://dx.doi.org/10.17179/excli2015-201
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author Kangarlu-Haghighi, Katayoon
Oryan, Shahrbanoo
Nasehi, Mohammad
Zarrindast, Mohammad-Reza
author_facet Kangarlu-Haghighi, Katayoon
Oryan, Shahrbanoo
Nasehi, Mohammad
Zarrindast, Mohammad-Reza
author_sort Kangarlu-Haghighi, Katayoon
collection PubMed
description The roles of GABAergic receptors of the Basolateral amygdala (BLA) in the cannabinoid CB1 receptor agonist (arachydonilcyclopropylamide; ACPA)-induced anxiolytic-like effect and aversive memory deficit in adult male mice were examined in elevated plus-maze task. Results showed that pre-test intra-peritoneal injection of ACPA induced anxiolytic-like effect (at dose of 0.05 mg/kg) and aversive memory deficit (at doses of 0.025 and 0.05 mg/kg). The results revealed that Pre-test intra-BLA infusion of muscimol (GABA(A) receptor agonist; at doses of 0.1 and 0.2 µg/mouse) or bicuculline (GABA(A) receptor antagonist; at all doses) impaired and did not alter aversive memory, respectively. All previous GABA agents did not have any effects on anxiety-like behaviors. Interestingly, pretreatment with a sub-threshold dose of muscimol (0.025 µg/mouse) and bicuculline (0.025 µg/mouse) did not alter anxiolytic-like behaviors induced by ACPA, while both drugs restored ACPA-induced amnesia. Moreover, muscimol or bicuculline increased and decreased ACPA-induced locomotor activity, respectively. Finally the data may indicate that BLA GABA(A )receptors have critical and different roles in anxiolytic-like effect, aversive memory deficit and locomotor activity induced by ACPA.
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spelling pubmed-46699092015-12-08 The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA Kangarlu-Haghighi, Katayoon Oryan, Shahrbanoo Nasehi, Mohammad Zarrindast, Mohammad-Reza EXCLI J Original Article The roles of GABAergic receptors of the Basolateral amygdala (BLA) in the cannabinoid CB1 receptor agonist (arachydonilcyclopropylamide; ACPA)-induced anxiolytic-like effect and aversive memory deficit in adult male mice were examined in elevated plus-maze task. Results showed that pre-test intra-peritoneal injection of ACPA induced anxiolytic-like effect (at dose of 0.05 mg/kg) and aversive memory deficit (at doses of 0.025 and 0.05 mg/kg). The results revealed that Pre-test intra-BLA infusion of muscimol (GABA(A) receptor agonist; at doses of 0.1 and 0.2 µg/mouse) or bicuculline (GABA(A) receptor antagonist; at all doses) impaired and did not alter aversive memory, respectively. All previous GABA agents did not have any effects on anxiety-like behaviors. Interestingly, pretreatment with a sub-threshold dose of muscimol (0.025 µg/mouse) and bicuculline (0.025 µg/mouse) did not alter anxiolytic-like behaviors induced by ACPA, while both drugs restored ACPA-induced amnesia. Moreover, muscimol or bicuculline increased and decreased ACPA-induced locomotor activity, respectively. Finally the data may indicate that BLA GABA(A )receptors have critical and different roles in anxiolytic-like effect, aversive memory deficit and locomotor activity induced by ACPA. Leibniz Research Centre for Working Environment and Human Factors 2015-05-11 /pmc/articles/PMC4669909/ /pubmed/26648818 http://dx.doi.org/10.17179/excli2015-201 Text en Copyright © 2015 Kangarlu-Haghighi et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Original Article
Kangarlu-Haghighi, Katayoon
Oryan, Shahrbanoo
Nasehi, Mohammad
Zarrindast, Mohammad-Reza
The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA
title The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA
title_full The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA
title_fullStr The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA
title_full_unstemmed The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA
title_short The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA
title_sort effect of bla gaba(a) receptors in anxiolytic-like effect and aversive memory deficit induced by acpa
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669909/
https://www.ncbi.nlm.nih.gov/pubmed/26648818
http://dx.doi.org/10.17179/excli2015-201
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