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Leukocyte telomere length and hippocampus volume: a meta-analysis
Leukocyte telomere length has been shown to correlate to hippocampus volume, but effect estimates differ in magnitude and are not uniformly positive. This study aimed primarily to investigate the relationship between leukocyte telomere length and hippocampus gray matter volume by meta-analysis and s...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670011/ https://www.ncbi.nlm.nih.gov/pubmed/26674112 http://dx.doi.org/10.12688/f1000research.7198.1 |
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author | Nilsonne, Gustav Tamm, Sandra Månsson, Kristoffer N. T. Åkerstedt, Torbjörn Lekander, Mats |
author_facet | Nilsonne, Gustav Tamm, Sandra Månsson, Kristoffer N. T. Åkerstedt, Torbjörn Lekander, Mats |
author_sort | Nilsonne, Gustav |
collection | PubMed |
description | Leukocyte telomere length has been shown to correlate to hippocampus volume, but effect estimates differ in magnitude and are not uniformly positive. This study aimed primarily to investigate the relationship between leukocyte telomere length and hippocampus gray matter volume by meta-analysis and secondarily to investigate possible effect moderators. Five studies were included with a total of 2107 participants, of which 1960 were contributed by one single influential study. A random-effects meta-analysis estimated the effect to r = 0.12 [95% CI -0.13, 0.37] in the presence of heterogeneity and a subjectively estimated moderate to high risk of bias. There was no evidence that apolipoprotein E (APOE) genotype was an effect moderator, nor that the ratio of leukocyte telomerase activity to telomere length was a better predictor than leukocyte telomere length for hippocampus volume. This meta-analysis, while not proving a positive relationship, also is not able to disprove the earlier finding of a positive correlation in the one large study included in analyses. We propose that a relationship between leukocyte telomere length and hippocamus volume may be mediated by transmigrating monocytes which differentiate into microglia in the brain parenchyma. |
format | Online Article Text |
id | pubmed-4670011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | F1000Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-46700112015-12-14 Leukocyte telomere length and hippocampus volume: a meta-analysis Nilsonne, Gustav Tamm, Sandra Månsson, Kristoffer N. T. Åkerstedt, Torbjörn Lekander, Mats F1000Res Systematic Review Leukocyte telomere length has been shown to correlate to hippocampus volume, but effect estimates differ in magnitude and are not uniformly positive. This study aimed primarily to investigate the relationship between leukocyte telomere length and hippocampus gray matter volume by meta-analysis and secondarily to investigate possible effect moderators. Five studies were included with a total of 2107 participants, of which 1960 were contributed by one single influential study. A random-effects meta-analysis estimated the effect to r = 0.12 [95% CI -0.13, 0.37] in the presence of heterogeneity and a subjectively estimated moderate to high risk of bias. There was no evidence that apolipoprotein E (APOE) genotype was an effect moderator, nor that the ratio of leukocyte telomerase activity to telomere length was a better predictor than leukocyte telomere length for hippocampus volume. This meta-analysis, while not proving a positive relationship, also is not able to disprove the earlier finding of a positive correlation in the one large study included in analyses. We propose that a relationship between leukocyte telomere length and hippocamus volume may be mediated by transmigrating monocytes which differentiate into microglia in the brain parenchyma. F1000Research 2015-10-15 /pmc/articles/PMC4670011/ /pubmed/26674112 http://dx.doi.org/10.12688/f1000research.7198.1 Text en Copyright: © 2015 Nilsonne G et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Systematic Review Nilsonne, Gustav Tamm, Sandra Månsson, Kristoffer N. T. Åkerstedt, Torbjörn Lekander, Mats Leukocyte telomere length and hippocampus volume: a meta-analysis |
title | Leukocyte telomere length and hippocampus volume: a meta-analysis |
title_full | Leukocyte telomere length and hippocampus volume: a meta-analysis |
title_fullStr | Leukocyte telomere length and hippocampus volume: a meta-analysis |
title_full_unstemmed | Leukocyte telomere length and hippocampus volume: a meta-analysis |
title_short | Leukocyte telomere length and hippocampus volume: a meta-analysis |
title_sort | leukocyte telomere length and hippocampus volume: a meta-analysis |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670011/ https://www.ncbi.nlm.nih.gov/pubmed/26674112 http://dx.doi.org/10.12688/f1000research.7198.1 |
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