IRE1α is an endogenous substrate of endoplasmic reticulum-associated degradation

Endoplasmic reticulum (ER)-associated degradation (ERAD) represents a principle quality control mechanism to clear misfolded proteins in the ER; however its physiological significance and the nature of endogenous ERAD substrates remain largely unexplored. Here we discover that IRE1α, the sensor of u...

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Detalles Bibliográficos
Autores principales: Sun, Shengyi, Shi, Guojun, Sha, Haibo, Ji, Yewei, Han, Xuemei, Shu, Xin, Ma, Hongming, Inoue, Takamasa, Gao, Beixue, Kim, Hana, Bu, Pengcheng, Guber, Robert D., Shen, Xiling, Lee, Ann-Hwee, Iwawaki, Takao, Paton, Adrienne W., Paton, James C., Fang, Deyu, Tsai, Billy, Yates, John R., Wu, Haoquan, Kersten, Sander, Long, Qiaoming, Duhamel, Gerald E., Simpson, Kenneth W., Qi, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670240/
https://www.ncbi.nlm.nih.gov/pubmed/26551274
http://dx.doi.org/10.1038/ncb3266

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