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Jaw mobility changes in patients with upper aerodigestive tract cancer undergoing radiation therapy
BACKGROUND: Radiation therapy is a therapeutic modality widely used for treatment of upper aerodigestive tract (UADT) neoplasms. However, its action is not restricted to tumor cells, and it may cause a variety of adverse reactions, including reduced jaw mobility. MATERIAL AND METHODS: A prospective...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medicina Oral S.L.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670249/ https://www.ncbi.nlm.nih.gov/pubmed/26449427 http://dx.doi.org/10.4317/medoral.20477 |
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author | Bragante, Karoline Wienandts, Patrícia Mozzini, Carolina Pinto, Rosélie da Motta, Neiro Jotz, Geraldo |
author_facet | Bragante, Karoline Wienandts, Patrícia Mozzini, Carolina Pinto, Rosélie da Motta, Neiro Jotz, Geraldo |
author_sort | Bragante, Karoline |
collection | PubMed |
description | BACKGROUND: Radiation therapy is a therapeutic modality widely used for treatment of upper aerodigestive tract (UADT) neoplasms. However, its action is not restricted to tumor cells, and it may cause a variety of adverse reactions, including reduced jaw mobility. MATERIAL AND METHODS: A prospective cohort study was conducted to assess changes in jaw mobility in patients with UADT cancer undergoing radiation therapy. RESULTS: Fifty-six patients completed the study. The results showed a significant reduction in mouth opening (p<0.001), right lateral excursion (p=0.038) and left lateral excursion (p=0.035) of the jaw, a significant increase in the presence (p<0.001) and severity of oral mucositis (p<0.001), and a significant decrease in performance status (p<0.001) after radiation therapy. Thirty-six patients (64.3%) exhibited reduction in mouth opening after treatment. The variables significantly associated with mouth opening reduction on bivariate analysis were: modification of diet (p=0.037), radiation field (p=0.024), presence of mucositis (p=0.003), and reduction in performance status (p=0.007). After adjustment by the multivariate model, the only variables that remained significantly associated with reduction in mouth opening were presence of mucositis (p=0.018) and reduction in performance status (p=0.47). CONCLUSIONS: These findings indicate that patients with upper aerodigestive tract cancer experience reduced jaw mobility after radiation therapy, which is strongly correlated with mucositis and reduced functional ability. Key words:Head and neck neoplasms, vertical dimension, radiation therapy, mucositis, temporomandibular joint, joint range of motion, trismus. |
format | Online Article Text |
id | pubmed-4670249 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medicina Oral S.L. |
record_format | MEDLINE/PubMed |
spelling | pubmed-46702492015-12-07 Jaw mobility changes in patients with upper aerodigestive tract cancer undergoing radiation therapy Bragante, Karoline Wienandts, Patrícia Mozzini, Carolina Pinto, Rosélie da Motta, Neiro Jotz, Geraldo Med Oral Patol Oral Cir Bucal Research BACKGROUND: Radiation therapy is a therapeutic modality widely used for treatment of upper aerodigestive tract (UADT) neoplasms. However, its action is not restricted to tumor cells, and it may cause a variety of adverse reactions, including reduced jaw mobility. MATERIAL AND METHODS: A prospective cohort study was conducted to assess changes in jaw mobility in patients with UADT cancer undergoing radiation therapy. RESULTS: Fifty-six patients completed the study. The results showed a significant reduction in mouth opening (p<0.001), right lateral excursion (p=0.038) and left lateral excursion (p=0.035) of the jaw, a significant increase in the presence (p<0.001) and severity of oral mucositis (p<0.001), and a significant decrease in performance status (p<0.001) after radiation therapy. Thirty-six patients (64.3%) exhibited reduction in mouth opening after treatment. The variables significantly associated with mouth opening reduction on bivariate analysis were: modification of diet (p=0.037), radiation field (p=0.024), presence of mucositis (p=0.003), and reduction in performance status (p=0.007). After adjustment by the multivariate model, the only variables that remained significantly associated with reduction in mouth opening were presence of mucositis (p=0.018) and reduction in performance status (p=0.47). CONCLUSIONS: These findings indicate that patients with upper aerodigestive tract cancer experience reduced jaw mobility after radiation therapy, which is strongly correlated with mucositis and reduced functional ability. Key words:Head and neck neoplasms, vertical dimension, radiation therapy, mucositis, temporomandibular joint, joint range of motion, trismus. Medicina Oral S.L. 2015-11 2015-10-09 /pmc/articles/PMC4670249/ /pubmed/26449427 http://dx.doi.org/10.4317/medoral.20477 Text en Copyright: © 2015 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Bragante, Karoline Wienandts, Patrícia Mozzini, Carolina Pinto, Rosélie da Motta, Neiro Jotz, Geraldo Jaw mobility changes in patients with upper aerodigestive tract cancer undergoing radiation therapy |
title | Jaw mobility changes in patients with upper aerodigestive
tract cancer undergoing radiation therapy |
title_full | Jaw mobility changes in patients with upper aerodigestive
tract cancer undergoing radiation therapy |
title_fullStr | Jaw mobility changes in patients with upper aerodigestive
tract cancer undergoing radiation therapy |
title_full_unstemmed | Jaw mobility changes in patients with upper aerodigestive
tract cancer undergoing radiation therapy |
title_short | Jaw mobility changes in patients with upper aerodigestive
tract cancer undergoing radiation therapy |
title_sort | jaw mobility changes in patients with upper aerodigestive
tract cancer undergoing radiation therapy |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670249/ https://www.ncbi.nlm.nih.gov/pubmed/26449427 http://dx.doi.org/10.4317/medoral.20477 |
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