Association of 4p14 TLR locus with antibodies to Helicobacter pylori

A genome-wide association study among Europeans related polymorphisms of the TLR locus at 4p14 and the FCGR2A locus at 1q23.3 to Helicobacter pylori serologic status. We replicated associations of 4p14 but not 1q23.3 with anti-H. pylori antibodies in 1,402 Finnish males. Importantly, our analysis clarified that the phenotype affected by 4p14 is quantitative level of these antibodies rather than association with seropositivity per se. Additionally, we annotated variants at 4p14 as expression quantitative trait loci associated with TLR6/10 and FAM114A1. Our findings suggest that 4p14 polymorphisms are linked to host immune response to H. pylori infection but not to its acquisition.