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Multifaceted role of β-arrestins in inflammation and disease

Arrestins are intracellular scaffolding proteins known to regulate a range of biochemical processes including G-protein coupled receptor (GPCR) desensitization, signal attenuation, receptor turnover and downstream signaling cascades. Their roles in regulation of signaling network have lately been ex...

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Detalles Bibliográficos
Autores principales: Sharma, Deepika, Parameswaran, Narayanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670277/
https://www.ncbi.nlm.nih.gov/pubmed/26378652
http://dx.doi.org/10.1038/gene.2015.37
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author Sharma, Deepika
Parameswaran, Narayanan
author_facet Sharma, Deepika
Parameswaran, Narayanan
author_sort Sharma, Deepika
collection PubMed
description Arrestins are intracellular scaffolding proteins known to regulate a range of biochemical processes including G-protein coupled receptor (GPCR) desensitization, signal attenuation, receptor turnover and downstream signaling cascades. Their roles in regulation of signaling network have lately been extended to receptors outside of the GPCR family, demonstrating their roles as important scaffolding proteins in various physiological processes including proliferation, differentiation, and apoptosis. Recent studies have demonstrated a critical role for arrestins in immunological processes including key functions in inflammatory signaling pathways. In this review, we provide a comprehensive analysis of the different functions of the arrestin family of proteins especially related to immunity and inflammatory diseases.
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spelling pubmed-46702772016-05-18 Multifaceted role of β-arrestins in inflammation and disease Sharma, Deepika Parameswaran, Narayanan Genes Immun Article Arrestins are intracellular scaffolding proteins known to regulate a range of biochemical processes including G-protein coupled receptor (GPCR) desensitization, signal attenuation, receptor turnover and downstream signaling cascades. Their roles in regulation of signaling network have lately been extended to receptors outside of the GPCR family, demonstrating their roles as important scaffolding proteins in various physiological processes including proliferation, differentiation, and apoptosis. Recent studies have demonstrated a critical role for arrestins in immunological processes including key functions in inflammatory signaling pathways. In this review, we provide a comprehensive analysis of the different functions of the arrestin family of proteins especially related to immunity and inflammatory diseases. 2015-09-17 2015-12 /pmc/articles/PMC4670277/ /pubmed/26378652 http://dx.doi.org/10.1038/gene.2015.37 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Sharma, Deepika
Parameswaran, Narayanan
Multifaceted role of β-arrestins in inflammation and disease
title Multifaceted role of β-arrestins in inflammation and disease
title_full Multifaceted role of β-arrestins in inflammation and disease
title_fullStr Multifaceted role of β-arrestins in inflammation and disease
title_full_unstemmed Multifaceted role of β-arrestins in inflammation and disease
title_short Multifaceted role of β-arrestins in inflammation and disease
title_sort multifaceted role of β-arrestins in inflammation and disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670277/
https://www.ncbi.nlm.nih.gov/pubmed/26378652
http://dx.doi.org/10.1038/gene.2015.37
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