Cargando…

Depletion of Fat Tregs Prevents Age-Associated Insulin Resistance

Age-associated insulin resistance (IR) and obesity-associated IR are two physiologically distinct forms of adult onset diabetes. While macrophage-driven inflammation is a core driver of obesity-associated IR(1–6), the underlying mechanisms of the obesity-independent yet highly prevalent age-associat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bapat, Sagar P., Suh, Jae Myoung, Fang, Sungsoon, Liu, Sihao, Zhang, Yang, Cheng, Albert, Zhou, Carmen, Liang, Yuqiong, LeBlanc, Mathias, Liddle, Christopher, Atkins, Annette R., Yu, Ruth T., Downes, Michael, Evans, Ronald M., Zheng, Ye
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670283/ https://www.ncbi.nlm.nih.gov/pubmed/26580014 http://dx.doi.org/10.1038/nature16151

Ejemplares similares

Metabolic control of regulatory T cell (Treg) survival and function by Lkb1
por: He, Nanhai, et al.
Publicado: (2017)

The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease
por: Chang, Christina, et al.
Publicado: (2019)

Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer
por: Suh, Jae Myoung, et al.
Publicado: (2014)

Clinical Grade Treg: GMP Isolation, Improvement of Purity by CD127(pos) Depletion, Treg Expansion, and Treg Cryopreservation
por: Peters, Jorieke H., et al.
Publicado: (2008)

Nuclear receptors rock around the clock
por: Zhao, Xuan, et al.
Publicado: (2014)

Nuclear receptors and metabolism: from feast to famine
por: Hong, Suk-Hyun, et al.
Publicado: (2014)

Transient Treg depletion enhances therapeutic anti‐cancer vaccination
por: Fisher, Scott A., et al.
Publicado: (2016)

Rapid Rebound of the Treg Compartment in DEREG Mice Limits the Impact of Treg Depletion on Mycobacterial Burden, but Prevents Autoimmunity
por: Berod, Luciana, et al.
Publicado: (2014)

Treg Depletion Inhibits Efficacy of Cancer Immunotherapy: Implications for Clinical Trials
por: Curtin, James F., et al.
Publicado: (2008)

Thyroid Hormone Receptor Repression Linked to Type I Pneumocyte Associated Respiratory Distress Syndrome
por: Pei, Liming, et al.
Publicado: (2011)

Combination of SLC administration and Tregs depletion is an attractive strategy for targeting hepatocellular carcinoma
por: Chen, Long, et al.
Publicado: (2013)

Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy
por: Sharma, Meenu, et al.
Publicado: (2020)

Immune evasive human islet-like organoids ameliorate diabetes
por: Yoshihara, Eiji, et al.
Publicado: (2020)

FXR mediates ILC-intrinsic responses to intestinal inflammation
por: Fu, Ting, et al.
Publicado: (2022)

A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
por: Jonker, Johan W., et al.
Publicado: (2012)

Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4(+) Treg in nonhuman primates
por: Wang, Zhaohui, et al.
Publicado: (2018)

The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens
por: Rodriguez-Barbosa, Jose-Ignacio, et al.
Publicado: (2020)

Mafosfamide Boosts GMI-HBVac against HBV via Treg Depletion in HBV-Infected Mice
por: Lin, Qin, et al.
Publicado: (2023)

Regulation of Circadian Behavior and Metabolism by Rev-erbα and Rev-erbβ
por: Cho, Han, et al.
Publicado: (2012)

Evidence and Mechanisms of Fat Depletion in Cancer
por: Ebadi, Maryam, et al.
Publicado: (2014)

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
por: Wang, Jianrong, et al.
Publicado: (2017)

Tregs depletion aggravates activation of astrocytes by modulating IL-10/GXP4 following cerebral infarction
por: Wang, Shuai, et al.
Publicado: (2023)

PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress
por: Yoon, Bo Kyung, et al.
Publicado: (2023)

TLR1/2 ligand enhances antitumor efficacy of CTLA-4 blockade by increasing intratumoral Treg depletion
por: Sharma, Naveen, et al.
Publicado: (2019)

Primary breast tumours but not lung metastases induce protective anti-tumour immune responses after Treg-depletion
por: Hughes, Ellyn, et al.
Publicado: (2020)

T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance
por: Yang, Xiaoshan, et al.
Publicado: (2021)

Vitamin D in Diabetes: Uncovering the Sunshine Hormone’s Role in Glucose Metabolism and Beyond
por: Wu, Jie, et al.
Publicado: (2023)

Insulin-binding protein-5 down-regulates the balance of Th17/Treg
por: Zhu, Mengyuan, et al.
Publicado: (2022)

Maximizing cancer therapy via complementary mechanisms of immune activation: PD-1 blockade, neoantigen vaccination, and Tregs depletion
por: D'Alise, Anna Morena, et al.
Publicado: (2021)

Fibroblast Growth Factor Signaling in Metabolic Regulation
por: Nies, Vera J. M., et al.
Publicado: (2016)

Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo
por: Fernandes, Ricardo A, et al.
Publicado: (2020)

Anti-CD25 Treatment Depletes Treg Cells and Decreases Disease Severity in Susceptible and Resistant Mice Infected with Paracoccidioides brasiliensis
por: Felonato, Maíra, et al.
Publicado: (2012)

Combining Intra-Tumoral Treg Depletion with Androgen Deprivation Therapy (ADT): Pre-Clinical Activity in the Myc-CaP Model
por: Shen, Ying-Chun, et al.
Publicado: (2017)

Role and mechanism of the Th17/Treg cell balance in the development and progression of insulin resistance
por: Tao, Limin, et al.
Publicado: (2019)

Shc depletion stimulates brown fat activity in vivo and in vitro
por: Tomilov, Alexey, et al.
Publicado: (2014)

The Impact of Gestational Weight Gain on Glucose and Insulin Physiology in Pregnancy—Does Timing Matter?
por: LeBlanc, Erin S, et al.
Publicado: (2021)

Treg/IL-17 Ratio and Treg Differentiation in Patients with COPD
por: Jin, Yang, et al.
Publicado: (2014)

Pathological conditions re-shape physiological Tregs into pathological Tregs
por: Yang, William Y, et al.
Publicado: (2015)

ICOS(+) Tregs: A Functional Subset of Tregs in Immune Diseases
por: Li, Dan-Yang, et al.
Publicado: (2020)

Cistromic and genetic evidence that the vitamin D receptor mediates susceptibility to latitude-dependent autoimmune diseases
por: Booth, D R, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ot0sjje0opkum9jnqtjcvdbv2m