NF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1

BACKGROUND: The nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) is required for pro-inflammatory effects of TNFα. Our previous studies demonstrated that PARP-1 mediates TNFα-induced NF-κB activation in glia. Here, we evaluated the mechanisms by which TNFα activates PARP-1 and PARP-1 mediates N...

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Detalles Bibliográficos
Autores principales: Vuong, Billy, Hogan-Cann, Adam D. J., Alano, Conrad C., Stevenson, Mackenzie, Chan, Wai Yee, Anderson, Christopher M., Swanson, Raymond A., Kauppinen, Tiina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670503/
https://www.ncbi.nlm.nih.gov/pubmed/26637332
http://dx.doi.org/10.1186/s12974-015-0448-8

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