The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer’s disease

BACKGROUND: Alzheimer’s disease (AD) is characterized by senile plaques, extracellular deposits composed primarily of amyloid–beta (Aβ), and neurofibrillary tangles, which are abnormal intracellular inclusions containing hyperphosphorylated tau. The amyloid cascade hypothesis posits that the deposit...

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Detalles Bibliográficos
Autores principales: Watanabe, Kiwamu, Uemura, Kengo, Asada, Megumi, Maesako, Masato, Akiyama, Haruhiko, Shimohama, Shun, Takahashi, Ryosuke, Kinoshita, Ayae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670528/
https://www.ncbi.nlm.nih.gov/pubmed/26637371
http://dx.doi.org/10.1186/s13041-015-0174-2

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