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Dual inhibition of Type I and Type III PI3 kinases increases tumor cell apoptosis in HER2+ breast cancers

INTRODUCTION: Human epidermal growth factor receptor-2 (HER2) gene amplification (HER2+) drives tumor cell growth and survival in ~25 % of breast cancers. HER2 signaling activates the type I phosphoinositide 3-kinase (PI3K), upon which these tumors rely. Consequently, inhibitors of HER2 and type I P...

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Detalles Bibliográficos
Autores principales:	Young, Christian D., Arteaga, Carlos L., Cook, Rebecca S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670529/ https://www.ncbi.nlm.nih.gov/pubmed/26637440 http://dx.doi.org/10.1186/s13058-015-0656-2

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