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Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases

Mitogen‐activated protein kinases (MAPK) are broadly used regulators of cellular signaling. However, how these enzymes can be involved in such a broad spectrum of physiological functions is not understood. Systematic discovery of MAPK networks both experimentally and in silico has been hindered beca...

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Detalles Bibliográficos
Autores principales: Zeke, András, Bastys, Tomas, Alexa, Anita, Garai, Ágnes, Mészáros, Bálint, Kirsch, Klára, Dosztányi, Zsuzsanna, Kalinina, Olga V, Reményi, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670726/
https://www.ncbi.nlm.nih.gov/pubmed/26538579
http://dx.doi.org/10.15252/msb.20156269