Cargando…
Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases
Mitogen‐activated protein kinases (MAPK) are broadly used regulators of cellular signaling. However, how these enzymes can be involved in such a broad spectrum of physiological functions is not understood. Systematic discovery of MAPK networks both experimentally and in silico has been hindered beca...
Autores principales: | Zeke, András, Bastys, Tomas, Alexa, Anita, Garai, Ágnes, Mészáros, Bálint, Kirsch, Klára, Dosztányi, Zsuzsanna, Kalinina, Olga V, Reményi, Attila |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670726/ https://www.ncbi.nlm.nih.gov/pubmed/26538579 http://dx.doi.org/10.15252/msb.20156269 |
Ejemplares similares
-
Systematic analysis of somatic mutations driving cancer: uncovering functional protein regions in disease development
por: Mészáros, Bálint, et al.
Publicado: (2016) -
Disordered Binding Regions and Linear Motifs—Bridging the Gap between Two Models of Molecular Recognition
por: Mészáros, Bálint, et al.
Publicado: (2012) -
Ancient Evolutionary Origin of Intrinsically Disordered Cancer Risk Regions
por: Pajkos, Mátyás, et al.
Publicado: (2020) -
Mutations of Intrinsically Disordered Protein Regions Can Drive Cancer but Lack Therapeutic Strategies
por: Mészáros, Bálint, et al.
Publicado: (2021) -
Systematic Discovery of FBXW7-Binding Phosphodegrons Highlights Mitogen-Activated Protein Kinases as Important Regulators of Intracellular Protein Levels
por: Singh, Neha, et al.
Publicado: (2022)