Frequency modulation of ERK activation dynamics rewires cell fate

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Transient versus sustained ERK MAP kinase (MAPK) activation dynamics induce proliferation versus differentiation in response to epidermal (EGF) or nerve (NGF) growth factors in PC‐12 cells. Duration of ERK activation has therefore been proposed to specify cell fate decisions. Using a biosensor to me...

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Detalles Bibliográficos
Autores principales: Ryu, Hyunryul, Chung, Minhwan, Dobrzyński, Maciej, Fey, Dirk, Blum, Yannick, Lee, Sung Sik, Peter, Matthias, Kholodenko, Boris N, Jeon, Noo Li, Pertz, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670727/
https://www.ncbi.nlm.nih.gov/pubmed/26613961
http://dx.doi.org/10.15252/msb.20156458
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