Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin

Induction of fetal hemoglobin (HbF) is considered a promising strategy in the treatment of β-thalassemia, in which production of adult hemoglobin (HbA) is impaired by mutations affecting the β-globin gene. Recent results indicate that B-cell lymphoma/leukemia 11A (BCL11A) is a major repressor of γ-g...

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Detalles Bibliográficos
Autores principales: Finotti, Alessia, Gasparello, Jessica, Breveglieri, Giulia, Cosenza, Lucia Carmela, Montagner, Giulia, Bresciani, Alberto, Altamura, Sergio, Bianchi, Nicoletta, Martini, Elisa, Gallerani, Eleonora, Borgatti, Monica, Gambari, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Inc 2015
Materias:
Normal Hematopoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670904/
https://www.ncbi.nlm.nih.gov/pubmed/26342260
http://dx.doi.org/10.1016/j.exphem.2015.08.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670904/
https://www.ncbi.nlm.nih.gov/pubmed/26342260
http://dx.doi.org/10.1016/j.exphem.2015.08.011

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