The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: implications for post-ischemic neuronal injury

Cyclopentenone prostaglandins (CyPGs), such as 15-deoxy-Δ(12,14)-prostaglandin J(2) (15dPGJ2), are reactive prostaglandin metabolites exerting a variety of biological effects. CyPGs are produced in ischemic brain and disrupt the ubiquitin-proteasome system (UPS). Ubiquitin-C-terminal hydrolase L1 (U...

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Detalles Bibliográficos
Autores principales: Liu, H, Li, W, Rose, M E, Hickey, R W, Chen, J, Uechi, G T, Balasubramani, M, Day, B W, Patel, K V, Graham, S H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670930/
https://www.ncbi.nlm.nih.gov/pubmed/26539913
http://dx.doi.org/10.1038/cddis.2015.323

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