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Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium
Fas ligand (FasL) triggers apoptosis of Fas-positive cells, and previous reports described FasL-induced cell death of Fas-positive photoreceptors following a retinal detachment. However, as FasL exists in membrane-bound (mFasL) and soluble (sFasL) forms, and is expressed on resident microglia and in...
Autores principales: | Matsumoto, H, Murakami, Y, Kataoka, K, Notomi, S, Mantopoulos, D, Trichonas, G, Miller, J W, Gregory, M S, Ksander, B R, Marshak-Rothstein, A, Vavvas, D G |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670938/ https://www.ncbi.nlm.nih.gov/pubmed/26583327 http://dx.doi.org/10.1038/cddis.2015.334 |
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