Smad4 represses the generation of memory-precursor effector T cells but is required for the differentiation of central memory T cells

The transcriptional regulation underlying the differentiation of CD8(+) effector and memory T cells remains elusive. Here, we show that 18-month-old mice lacking the transcription factor Smad4 (homolog 4 of mothers against decapentaplegic, Drosophila), a key intracellular signaling effector for the...

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Detalles Bibliográficos
Autores principales: Cao, J, Zhang, X, Wang, Q, Qiu, G, Hou, C, Wang, J, Cheng, Q, Lan, Y, Han, H, Shen, H, Zhang, Y, Yang, X, Shen, B, Zhang, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670941/
https://www.ncbi.nlm.nih.gov/pubmed/26583325
http://dx.doi.org/10.1038/cddis.2015.337

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