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Loss in MCL-1 function sensitizes non-Hodgkin's lymphoma cell lines to the BCL-2-selective inhibitor venetoclax (ABT-199)

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As a population, non-Hodgkin's lymphoma (NHL) cell lines positive for the t(14;18) translocation and/or possessing elevated BCL2 copy number (CN; BCL2(High)) are exquisitely sensitive to navitoclax or the B-cell lymphoma protein-2 (BCL-2)-selective inhibitor venetoclax. Despite this, some BCL2(...

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Detalles Bibliográficos
Autores principales:	Phillips, D C, Xiao, Y, Lam, L T, Litvinovich, E, Roberts-Rapp, L, Souers, A J, Leverson, J D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670945/ https://www.ncbi.nlm.nih.gov/pubmed/26565405 http://dx.doi.org/10.1038/bcj.2015.88

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