Loss in MCL-1 function sensitizes non-Hodgkin's lymphoma cell lines to the BCL-2-selective inhibitor venetoclax (ABT-199)

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As a population, non-Hodgkin's lymphoma (NHL) cell lines positive for the t(14;18) translocation and/or possessing elevated BCL2 copy number (CN; BCL2(High)) are exquisitely sensitive to navitoclax or the B-cell lymphoma protein-2 (BCL-2)-selective inhibitor venetoclax. Despite this, some BCL2(...

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Detalles Bibliográficos
Autores principales: Phillips, D C, Xiao, Y, Lam, L T, Litvinovich, E, Roberts-Rapp, L, Souers, A J, Leverson, J D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670945/
https://www.ncbi.nlm.nih.gov/pubmed/26565405
http://dx.doi.org/10.1038/bcj.2015.88
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