Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development

The aim of our study was to evaluate if Sirt6, a NAD + dependent histone deacetylase, plays a protective role in cartilage degeneration by suppressing cellular senescence and inflammatory responses. The expression level of sirt6 in normal and OA human knee articular cartilage was compared by immunof...

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Detalles Bibliográficos
Autores principales: Wu, Yaosen, Chen, Linwei, Wang, Ye, Li, Wanli, Lin, Yan, Yu, Dongsheng, Zhang, Liang, Li, Fangcai, Pan, Zhijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671011/
https://www.ncbi.nlm.nih.gov/pubmed/26639398
http://dx.doi.org/10.1038/srep17602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671011/
https://www.ncbi.nlm.nih.gov/pubmed/26639398
http://dx.doi.org/10.1038/srep17602

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