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Functional properties of resting state networks in healthy full-term newborns
Objective, early, and non-invasive assessment of brain function in high-risk newborns is critical to initiate timely interventions and to minimize long-term neurodevelopmental disabilities. A prerequisite to identifying deviations from normal, however, is the availability of baseline measures of bra...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671028/ https://www.ncbi.nlm.nih.gov/pubmed/26639607 http://dx.doi.org/10.1038/srep17755 |
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author | De Asis-Cruz, Josepheen Bouyssi-Kobar, Marine Evangelou, Iordanis Vezina, Gilbert Limperopoulos, Catherine |
author_facet | De Asis-Cruz, Josepheen Bouyssi-Kobar, Marine Evangelou, Iordanis Vezina, Gilbert Limperopoulos, Catherine |
author_sort | De Asis-Cruz, Josepheen |
collection | PubMed |
description | Objective, early, and non-invasive assessment of brain function in high-risk newborns is critical to initiate timely interventions and to minimize long-term neurodevelopmental disabilities. A prerequisite to identifying deviations from normal, however, is the availability of baseline measures of brain function derived from healthy, full-term newborns. Recent advances in functional MRI combined with graph theoretic techniques may provide important, currently unavailable, quantitative markers of normal neurodevelopment. In the current study, we describe important properties of resting state networks in 60 healthy, full-term, unsedated newborns. The neonate brain exhibited an efficient and economical small world topology: densely connected nearby regions, sparse, but well integrated, distant connections, a small world index greater than 1, and global/local efficiency greater than network cost. These networks showed a heavy-tailed degree distribution, suggesting the presence of regions that are more richly connected to others (‘hubs’). These hubs, identified using degree and betweenness centrality measures, show a more mature hub organization than previously reported. Targeted attacks on hubs show that neonate networks are more resilient than simulated scale-free networks. Networks fragmented faster and global efficiency decreased faster when betweenness, as opposed to degree, hubs were attacked suggesting a more influential role of betweenness hub in the neonate network. |
format | Online Article Text |
id | pubmed-4671028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46710282015-12-11 Functional properties of resting state networks in healthy full-term newborns De Asis-Cruz, Josepheen Bouyssi-Kobar, Marine Evangelou, Iordanis Vezina, Gilbert Limperopoulos, Catherine Sci Rep Article Objective, early, and non-invasive assessment of brain function in high-risk newborns is critical to initiate timely interventions and to minimize long-term neurodevelopmental disabilities. A prerequisite to identifying deviations from normal, however, is the availability of baseline measures of brain function derived from healthy, full-term newborns. Recent advances in functional MRI combined with graph theoretic techniques may provide important, currently unavailable, quantitative markers of normal neurodevelopment. In the current study, we describe important properties of resting state networks in 60 healthy, full-term, unsedated newborns. The neonate brain exhibited an efficient and economical small world topology: densely connected nearby regions, sparse, but well integrated, distant connections, a small world index greater than 1, and global/local efficiency greater than network cost. These networks showed a heavy-tailed degree distribution, suggesting the presence of regions that are more richly connected to others (‘hubs’). These hubs, identified using degree and betweenness centrality measures, show a more mature hub organization than previously reported. Targeted attacks on hubs show that neonate networks are more resilient than simulated scale-free networks. Networks fragmented faster and global efficiency decreased faster when betweenness, as opposed to degree, hubs were attacked suggesting a more influential role of betweenness hub in the neonate network. Nature Publishing Group 2015-12-07 /pmc/articles/PMC4671028/ /pubmed/26639607 http://dx.doi.org/10.1038/srep17755 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article De Asis-Cruz, Josepheen Bouyssi-Kobar, Marine Evangelou, Iordanis Vezina, Gilbert Limperopoulos, Catherine Functional properties of resting state networks in healthy full-term newborns |
title | Functional properties of resting state networks in healthy full-term newborns |
title_full | Functional properties of resting state networks in healthy full-term newborns |
title_fullStr | Functional properties of resting state networks in healthy full-term newborns |
title_full_unstemmed | Functional properties of resting state networks in healthy full-term newborns |
title_short | Functional properties of resting state networks in healthy full-term newborns |
title_sort | functional properties of resting state networks in healthy full-term newborns |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671028/ https://www.ncbi.nlm.nih.gov/pubmed/26639607 http://dx.doi.org/10.1038/srep17755 |
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