Complete re-sequencing of a 2Mb topological domain encompassing the FTO/IRXB genes identifies a novel obesity-associated region upstream of IRX5

BACKGROUND: Association studies have identified a number of loci that contribute to an increased body mass index (BMI), the strongest of which is in the first intron of the FTO gene on human chromosome 16q12.2. However, this region is both non-coding and under strong linkage disequilibrium, making i...

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Detalles Bibliográficos
Autores principales: Hunt, Lilian E., Noyvert, Boris, Bhaw-Rosun, Leena, Sesay, Abdul K., Paternoster, Lavinia, Nohr, Ellen A., Davey Smith, George, Tommerup, Niels, Sørensen, Thorkild I. A., Elgar, Greg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671217/
https://www.ncbi.nlm.nih.gov/pubmed/26642925
http://dx.doi.org/10.1186/s13073-015-0250-3

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