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TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN

Agonists for TLR9 and Stimulator of IFN Gene (STING) act as vaccine adjuvants that induce type-1 immune responses. However, currently available CpG oligodeoxynucleotide (ODN) (K-type) induces IFNs only weakly and STING ligands rather induce type-2 immune responses, limiting their potential therapeut...

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Detalles Bibliográficos
Autores principales:	Temizoz, Burcu, Kuroda, Etsushi, Ohata, Keiichi, Jounai, Nao, Ozasa, Koji, Kobiyama, Kouji, Aoshi, Taiki, Ishii, Ken J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Innate Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671267/ https://www.ncbi.nlm.nih.gov/pubmed/25529558 http://dx.doi.org/10.1002/eji.201445132

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