Novel Molecular Approaches in Heart Failure: Seven Trans-Membrane Receptors Signaling in the Heart and Circulating Blood Leukocytes

Heart failure (HF) is the result of molecular, cellular, and structural changes induced by cardiac load or injury. A complex network of signaling pathways have been involved in the development and progression of cardiac dysfunction. In this review, we summarize the pivotal role of seven trans-membra...

Descripción completa

Detalles Bibliográficos
Autores principales: Schiattarella, Gabriele Giacomo, Magliulo, Fabio, Cattaneo, Fabio, Gargiulo, Giuseppe, Sannino, Anna, Franzone, Anna, Oliveti, Marco, Perrino, Cinzia, Trimarco, Bruno, Esposito, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671356/
https://www.ncbi.nlm.nih.gov/pubmed/26664885
http://dx.doi.org/10.3389/fcvm.2015.00013
_version_ 1782404392863924224
author Schiattarella, Gabriele Giacomo
Magliulo, Fabio
Cattaneo, Fabio
Gargiulo, Giuseppe
Sannino, Anna
Franzone, Anna
Oliveti, Marco
Perrino, Cinzia
Trimarco, Bruno
Esposito, Giovanni
author_facet Schiattarella, Gabriele Giacomo
Magliulo, Fabio
Cattaneo, Fabio
Gargiulo, Giuseppe
Sannino, Anna
Franzone, Anna
Oliveti, Marco
Perrino, Cinzia
Trimarco, Bruno
Esposito, Giovanni
author_sort Schiattarella, Gabriele Giacomo
collection PubMed
description Heart failure (HF) is the result of molecular, cellular, and structural changes induced by cardiac load or injury. A complex network of signaling pathways have been involved in the development and progression of cardiac dysfunction. In this review, we summarize the pivotal role of seven trans-membrane receptors (7TMRs), also called G-protein-coupled receptors (GPCRs), in HF. Moreover, we will discuss the current knowledge on the potential mirroring of 7TMR signaling between circulating blood leukocytes and the heart, and the related future possibilities in the management of HF patients.
format Online
Article
Text
id pubmed-4671356
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-46713562015-12-10 Novel Molecular Approaches in Heart Failure: Seven Trans-Membrane Receptors Signaling in the Heart and Circulating Blood Leukocytes Schiattarella, Gabriele Giacomo Magliulo, Fabio Cattaneo, Fabio Gargiulo, Giuseppe Sannino, Anna Franzone, Anna Oliveti, Marco Perrino, Cinzia Trimarco, Bruno Esposito, Giovanni Front Cardiovasc Med Cardiovascular Medicine Heart failure (HF) is the result of molecular, cellular, and structural changes induced by cardiac load or injury. A complex network of signaling pathways have been involved in the development and progression of cardiac dysfunction. In this review, we summarize the pivotal role of seven trans-membrane receptors (7TMRs), also called G-protein-coupled receptors (GPCRs), in HF. Moreover, we will discuss the current knowledge on the potential mirroring of 7TMR signaling between circulating blood leukocytes and the heart, and the related future possibilities in the management of HF patients. Frontiers Media S.A. 2015-03-16 /pmc/articles/PMC4671356/ /pubmed/26664885 http://dx.doi.org/10.3389/fcvm.2015.00013 Text en Copyright © 2015 Schiattarella, Magliulo, Cattaneo, Gargiulo, Sannino, Franzone, Oliveti, Perrino, Trimarco and Esposito. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Schiattarella, Gabriele Giacomo
Magliulo, Fabio
Cattaneo, Fabio
Gargiulo, Giuseppe
Sannino, Anna
Franzone, Anna
Oliveti, Marco
Perrino, Cinzia
Trimarco, Bruno
Esposito, Giovanni
Novel Molecular Approaches in Heart Failure: Seven Trans-Membrane Receptors Signaling in the Heart and Circulating Blood Leukocytes
title Novel Molecular Approaches in Heart Failure: Seven Trans-Membrane Receptors Signaling in the Heart and Circulating Blood Leukocytes
title_full Novel Molecular Approaches in Heart Failure: Seven Trans-Membrane Receptors Signaling in the Heart and Circulating Blood Leukocytes
title_fullStr Novel Molecular Approaches in Heart Failure: Seven Trans-Membrane Receptors Signaling in the Heart and Circulating Blood Leukocytes
title_full_unstemmed Novel Molecular Approaches in Heart Failure: Seven Trans-Membrane Receptors Signaling in the Heart and Circulating Blood Leukocytes
title_short Novel Molecular Approaches in Heart Failure: Seven Trans-Membrane Receptors Signaling in the Heart and Circulating Blood Leukocytes
title_sort novel molecular approaches in heart failure: seven trans-membrane receptors signaling in the heart and circulating blood leukocytes
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671356/
https://www.ncbi.nlm.nih.gov/pubmed/26664885
http://dx.doi.org/10.3389/fcvm.2015.00013
work_keys_str_mv AT schiattarellagabrielegiacomo novelmolecularapproachesinheartfailureseventransmembranereceptorssignalingintheheartandcirculatingbloodleukocytes
AT magliulofabio novelmolecularapproachesinheartfailureseventransmembranereceptorssignalingintheheartandcirculatingbloodleukocytes
AT cattaneofabio novelmolecularapproachesinheartfailureseventransmembranereceptorssignalingintheheartandcirculatingbloodleukocytes
AT gargiulogiuseppe novelmolecularapproachesinheartfailureseventransmembranereceptorssignalingintheheartandcirculatingbloodleukocytes
AT sanninoanna novelmolecularapproachesinheartfailureseventransmembranereceptorssignalingintheheartandcirculatingbloodleukocytes
AT franzoneanna novelmolecularapproachesinheartfailureseventransmembranereceptorssignalingintheheartandcirculatingbloodleukocytes
AT olivetimarco novelmolecularapproachesinheartfailureseventransmembranereceptorssignalingintheheartandcirculatingbloodleukocytes
AT perrinocinzia novelmolecularapproachesinheartfailureseventransmembranereceptorssignalingintheheartandcirculatingbloodleukocytes
AT trimarcobruno novelmolecularapproachesinheartfailureseventransmembranereceptorssignalingintheheartandcirculatingbloodleukocytes
AT espositogiovanni novelmolecularapproachesinheartfailureseventransmembranereceptorssignalingintheheartandcirculatingbloodleukocytes

Ejemplares similares