Dobutamine-Induced Strain and Strain Rate Predict Viability Following Fibrinolytic Therapy in Patients with ST-Elevation Myocardial Infarction

Background: Low-dose dobutamine stress echocardiography is increasingly used for identifying myocardial viability. Aim: We explored whether dobutamine-induced strain (S) and strain rate (SR) can identify myocardial viability following fibrinolytic therapy for ST-segment-elevation myocardial infarction (STEMI), taking (99m)Tc-sestamibi scintigraphy as the “gold standard” for diagnosis. Methods: We enrolled 60 consecutive patients presenting for myocardial viability assessment at least 4 weeks following STEMI. S and SR were measured by tissue Doppler imaging individually for all myocardial segments under low-dose dobutamine stress echocardiography. Patients underwent resting (99m)Tc-sestamibi scintigraphy using the standard imaging technique. Based on the results of (99m)Tc-sestamibi scintigraphy, the dobutamine-induced S and SR were compared between viable and non-viable segments. Receiver-operating characteristics curve was constructed to determine the cutoff value of the dobutamine-induced S and SR that best identifies viability. Results: The dobutamine-induced S and SR were significantly higher in viable compared with non-viable segments, a finding that was consistent for most individual myocardial segments (10 out of 16 for S and 11 out of 16 for SR). A cutoff value ranging from −8.5 to −9.6% for the S identified viability in apical and mid- segments, whereas a cutoff value ranging from −11.5 to −21.5% identified viability in basal segments. Similarly, a cutoff value ranging from −0.5 to −1.2 s(−1) for the SR identified viability in apical and mid-segments, whereas a cutoff value ranging from −1.4 to −1.7/s(−1) identified viability in basal segments. Conclusion: In patients undergoing viability assessment following fibrinolytic therapy for STEMI, the dobutamine-induced S and SR were higher in viable versus non-viable segments. A cutoff value of dobutamine-induced S and SR identified viability in most individual myocardial segments.