Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic tumor with a dismal prognosis for most patients. Fibrosis and inflammation are hallmarks of tumor desmoplasia. We have previously demonstrated that preventing the activation of pancreatic stellate cells (PSCs) and alleviati...

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Detalles Bibliográficos
Autores principales: Incio, Joao, Suboj, Priya, Chin, Shan M., Vardam-Kaur, Trupti, Liu, Hao, Hato, Tai, Babykutty, Suboj, Chen, Ivy, Deshpande, Vikram, Jain, Rakesh K., Fukumura, Dai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671732/
https://www.ncbi.nlm.nih.gov/pubmed/26641266
http://dx.doi.org/10.1371/journal.pone.0141392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671732/
https://www.ncbi.nlm.nih.gov/pubmed/26641266
http://dx.doi.org/10.1371/journal.pone.0141392

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