New alternative splicing BCR/ABL-OOF shows an oncogenic role by lack of inhibition of BCR GTPase activity and an increased of persistence of Rac activation in chronic myeloid leukemia

In Chronic Myeloid Leukemia 80% of patients present alternative splice variants involving BCR exons 1, 13 or 14 and ABL exon 4, with a consequent impairment in the reading frame of the ABL gene. Therefore BCR/ABL fusion proteins (BCR/ABL-OOF) are characterized by an in-frame BCR portion followed by...

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Detalles Bibliográficos
Autores principales: Panuzzo, Cristina, Volpe, Gisella, Rocchietti, Elisa Cibrario, Casnici, Claudia, Crotta, Katia, Crivellaro, Sabrina, Carrà, Giovanna, Lorenzatti, Roberta, Peracino, Barbara, Torti, Davide, Morotti, Alessandro, Camacho-Leal, Maria Pilar, Defilippi, Paola, Marelli, Ornella, Saglio, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671955/
https://www.ncbi.nlm.nih.gov/pubmed/26682280

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