Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

DNA polymerase theta (Polθ) has been identified as a crucial alternative non-homologous end-joining factor in mammalian cells. Polθ is upregulated in a range of cancer cell types defective in homologous recombination, and knockdown has been shown to inhibit cell survival in a subset of these, making...

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Detalles Bibliográficos
Autores principales: Newman, Joseph A., Cooper, Christopher D.O., Aitkenhead, Hazel, Gileadi, Opher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671958/
https://www.ncbi.nlm.nih.gov/pubmed/26636256
http://dx.doi.org/10.1016/j.str.2015.10.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671958/
https://www.ncbi.nlm.nih.gov/pubmed/26636256
http://dx.doi.org/10.1016/j.str.2015.10.014

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