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Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

DNA polymerase theta (Polθ) has been identified as a crucial alternative non-homologous end-joining factor in mammalian cells. Polθ is upregulated in a range of cancer cell types defective in homologous recombination, and knockdown has been shown to inhibit cell survival in a subset of these, making...

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Detalles Bibliográficos
Autores principales:	Newman, Joseph A., Cooper, Christopher D.O., Aitkenhead, Hazel, Gileadi, Opher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671958/ https://www.ncbi.nlm.nih.gov/pubmed/26636256 http://dx.doi.org/10.1016/j.str.2015.10.014

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