Unusual massive bone marrow fibrosis in acute promyelocytic leukemia following arsenic trioxide therapy

Bone marrow fibrosis has been associated with different types of non-neoplastic conditions like granulomatous and autoimmune diseases and a variety of neoplastic disorders such as acute megakaryoblastic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma and myeloproliferative neoplsms. Therapy induced...

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Detalles Bibliográficos
Autores principales: Venkatesan, S., Purohit, Abhishek, Ahuja, Ankur, Chandra, Dinesh, Aggarwal, Mukul, Amrita, R., Kumar, Ravi, Mahapatra, Manoranjan, Pati, Hara P., Tyagi, Seema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672073/
https://www.ncbi.nlm.nih.gov/pubmed/26716080
http://dx.doi.org/10.1016/j.lrr.2015.06.001
Descripción
Sumario:Bone marrow fibrosis has been associated with different types of non-neoplastic conditions like granulomatous and autoimmune diseases and a variety of neoplastic disorders such as acute megakaryoblastic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma and myeloproliferative neoplsms. Therapy induced fibrosis is a rare phenomenon. Here we report a case of an incidentally diagnosed acute promyelocytic leukemia (APL) with t(11;17) which was treated with arsenic trioxide (ATO) for 45 days. However, the patient did not go into remission and developed massive fibrosis of bone marrow. Literature search does not reveal such documented marrow fibrosis following therapy with ATO in a case of APL.

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