Unusual massive bone marrow fibrosis in acute promyelocytic leukemia following arsenic trioxide therapy

Bone marrow fibrosis has been associated with different types of non-neoplastic conditions like granulomatous and autoimmune diseases and a variety of neoplastic disorders such as acute megakaryoblastic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma and myeloproliferative neoplsms. Therapy induced...

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Autores principales: Venkatesan, S., Purohit, Abhishek, Ahuja, Ankur, Chandra, Dinesh, Aggarwal, Mukul, Amrita, R., Kumar, Ravi, Mahapatra, Manoranjan, Pati, Hara P., Tyagi, Seema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672073/
https://www.ncbi.nlm.nih.gov/pubmed/26716080
http://dx.doi.org/10.1016/j.lrr.2015.06.001
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author Venkatesan, S.
Purohit, Abhishek
Ahuja, Ankur
Chandra, Dinesh
Aggarwal, Mukul
Amrita, R.
Kumar, Ravi
Mahapatra, Manoranjan
Pati, Hara P.
Tyagi, Seema
author_facet Venkatesan, S.
Purohit, Abhishek
Ahuja, Ankur
Chandra, Dinesh
Aggarwal, Mukul
Amrita, R.
Kumar, Ravi
Mahapatra, Manoranjan
Pati, Hara P.
Tyagi, Seema
author_sort Venkatesan, S.
collection PubMed
description Bone marrow fibrosis has been associated with different types of non-neoplastic conditions like granulomatous and autoimmune diseases and a variety of neoplastic disorders such as acute megakaryoblastic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma and myeloproliferative neoplsms. Therapy induced fibrosis is a rare phenomenon. Here we report a case of an incidentally diagnosed acute promyelocytic leukemia (APL) with t(11;17) which was treated with arsenic trioxide (ATO) for 45 days. However, the patient did not go into remission and developed massive fibrosis of bone marrow. Literature search does not reveal such documented marrow fibrosis following therapy with ATO in a case of APL.
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spelling pubmed-46720732015-12-29 Unusual massive bone marrow fibrosis in acute promyelocytic leukemia following arsenic trioxide therapy Venkatesan, S. Purohit, Abhishek Ahuja, Ankur Chandra, Dinesh Aggarwal, Mukul Amrita, R. Kumar, Ravi Mahapatra, Manoranjan Pati, Hara P. Tyagi, Seema Leuk Res Rep Article Bone marrow fibrosis has been associated with different types of non-neoplastic conditions like granulomatous and autoimmune diseases and a variety of neoplastic disorders such as acute megakaryoblastic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma and myeloproliferative neoplsms. Therapy induced fibrosis is a rare phenomenon. Here we report a case of an incidentally diagnosed acute promyelocytic leukemia (APL) with t(11;17) which was treated with arsenic trioxide (ATO) for 45 days. However, the patient did not go into remission and developed massive fibrosis of bone marrow. Literature search does not reveal such documented marrow fibrosis following therapy with ATO in a case of APL. Elsevier 2015-07-15 /pmc/articles/PMC4672073/ /pubmed/26716080 http://dx.doi.org/10.1016/j.lrr.2015.06.001 Text en © 2015 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Venkatesan, S.
Purohit, Abhishek
Ahuja, Ankur
Chandra, Dinesh
Aggarwal, Mukul
Amrita, R.
Kumar, Ravi
Mahapatra, Manoranjan
Pati, Hara P.
Tyagi, Seema
Unusual massive bone marrow fibrosis in acute promyelocytic leukemia following arsenic trioxide therapy
title Unusual massive bone marrow fibrosis in acute promyelocytic leukemia following arsenic trioxide therapy
title_full Unusual massive bone marrow fibrosis in acute promyelocytic leukemia following arsenic trioxide therapy
title_fullStr Unusual massive bone marrow fibrosis in acute promyelocytic leukemia following arsenic trioxide therapy
title_full_unstemmed Unusual massive bone marrow fibrosis in acute promyelocytic leukemia following arsenic trioxide therapy
title_short Unusual massive bone marrow fibrosis in acute promyelocytic leukemia following arsenic trioxide therapy
title_sort unusual massive bone marrow fibrosis in acute promyelocytic leukemia following arsenic trioxide therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672073/
https://www.ncbi.nlm.nih.gov/pubmed/26716080
http://dx.doi.org/10.1016/j.lrr.2015.06.001
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