A Novel Class of HIV-1 Antiviral Agents Targeting HIV via a SUMOylation-Dependent Mechanism

We have recently identified a chemotype of small ubiquitin-like modifier (SUMO)-specific protease (SENP) inhibitors. Prior to the discovery of their SENP inhibitory activity, these compounds were found to inhibit HIV replication, but with an unknown mechanism. In this study, we investigated the mech...

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Detalles Bibliográficos
Autores principales: Madu, Ikenna G., Li, Shirley, Li, Baozong, Li, Haitang, Chang, Tammy, Li, Yi-Jia, Vega, Ramir, Rossi, John, Yee, Jiing-Kuan, Zaia, John, Chen, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672295/
https://www.ncbi.nlm.nih.gov/pubmed/26643614
http://dx.doi.org/10.1038/srep17808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672295/
https://www.ncbi.nlm.nih.gov/pubmed/26643614
http://dx.doi.org/10.1038/srep17808

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