Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia

The kynurenine pathway of tryptophan metabolism has been implicated in the pathophysiology of psychiatric disorders, including schizophrenia. We report here that the kynurenine metabolite, xanturenic acid (XA), interacts with, and activates mGlu2 and mGlu3 metabotropic glutamate receptors in heterol...

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Detalles Bibliográficos
Autores principales: Fazio, Francesco, Lionetto, Luana, Curto, Martina, Iacovelli, Luisa, Cavallari, Michele, Zappulla, Cristina, Ulivieri, Martina, Napoletano, Flavia, Capi, Matilde, Corigliano, Valentina, Scaccianoce, Sergio, Caruso, Alessandra, Miele, Jessica, De Fusco, Antonio, Di Menna, Luisa, Comparelli, Anna, De Carolis, Antonella, Gradini, Roberto, Nisticò, Robert, De Blasi, Antonio, Girardi, Paolo, Bruno, Valeria, Battaglia, Giuseppe, Nicoletti, Ferdinando, Simmaco, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672300/
https://www.ncbi.nlm.nih.gov/pubmed/26643205
http://dx.doi.org/10.1038/srep17799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672300/
https://www.ncbi.nlm.nih.gov/pubmed/26643205
http://dx.doi.org/10.1038/srep17799

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