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Body composition in young female eating-disorder patients with severe weight loss and controls: evidence from the four-component model and evaluation of DXA

BACKGROUND/OBJECTIVES: Whether fat-free mass (FFM) and its components are depleted in eating-disorder (ED) patients is uncertain. Dual energy X-ray absorptiometry (DXA) is widely used to assess body composition in pediatric ED patients; however, its accuracy in underweight populations remains unknow...

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Autores principales: Wells, J C K, Haroun, D, Williams, J E, Nicholls, D, Darch, T, Eaton, S, Fewtrell, M S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672328/
https://www.ncbi.nlm.nih.gov/pubmed/26173868
http://dx.doi.org/10.1038/ejcn.2015.111
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author Wells, J C K
Haroun, D
Williams, J E
Nicholls, D
Darch, T
Eaton, S
Fewtrell, M S
author_facet Wells, J C K
Haroun, D
Williams, J E
Nicholls, D
Darch, T
Eaton, S
Fewtrell, M S
author_sort Wells, J C K
collection PubMed
description BACKGROUND/OBJECTIVES: Whether fat-free mass (FFM) and its components are depleted in eating-disorder (ED) patients is uncertain. Dual energy X-ray absorptiometry (DXA) is widely used to assess body composition in pediatric ED patients; however, its accuracy in underweight populations remains unknown. We aimed (1) to assess body composition of young females with ED involving substantial weight loss, relative to healthy controls using the four-component (4C) model, and (2) to explore the validity of DXA body composition assessment in ED patients. SUBJECTS/METHODS: Body composition of 13 females with ED and 117 controls, aged 10–18 years, was investigated using the 4C model. Accuracy of DXA for estimation of FFM and fat mass (FM) was tested using the approach of Bland and Altman. RESULTS: Adjusting for age, height and pubertal stage, ED patients had significantly lower whole-body FM, FFM, protein mass (PM) and mineral mass (MM) compared with controls. Trunk and limb FM and limb lean soft tissue were significantly lower in ED patients. However, no significant difference in the hydration of FFM was detected. Compared with the 4C model, DXA overestimated FM by 5±36% and underestimated FFM by 1±9% in ED patients. CONCLUSION: Our study confirms that ED patients are depleted not only in FM but also in FFM, PM and MM. DXA has limitations for estimating body composition in individual young female ED patients.
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spelling pubmed-46723282015-12-17 Body composition in young female eating-disorder patients with severe weight loss and controls: evidence from the four-component model and evaluation of DXA Wells, J C K Haroun, D Williams, J E Nicholls, D Darch, T Eaton, S Fewtrell, M S Eur J Clin Nutr Body Composition Highlights Original Article BACKGROUND/OBJECTIVES: Whether fat-free mass (FFM) and its components are depleted in eating-disorder (ED) patients is uncertain. Dual energy X-ray absorptiometry (DXA) is widely used to assess body composition in pediatric ED patients; however, its accuracy in underweight populations remains unknown. We aimed (1) to assess body composition of young females with ED involving substantial weight loss, relative to healthy controls using the four-component (4C) model, and (2) to explore the validity of DXA body composition assessment in ED patients. SUBJECTS/METHODS: Body composition of 13 females with ED and 117 controls, aged 10–18 years, was investigated using the 4C model. Accuracy of DXA for estimation of FFM and fat mass (FM) was tested using the approach of Bland and Altman. RESULTS: Adjusting for age, height and pubertal stage, ED patients had significantly lower whole-body FM, FFM, protein mass (PM) and mineral mass (MM) compared with controls. Trunk and limb FM and limb lean soft tissue were significantly lower in ED patients. However, no significant difference in the hydration of FFM was detected. Compared with the 4C model, DXA overestimated FM by 5±36% and underestimated FFM by 1±9% in ED patients. CONCLUSION: Our study confirms that ED patients are depleted not only in FM but also in FFM, PM and MM. DXA has limitations for estimating body composition in individual young female ED patients. Nature Publishing Group 2015-12 2015-07-15 /pmc/articles/PMC4672328/ /pubmed/26173868 http://dx.doi.org/10.1038/ejcn.2015.111 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Body Composition Highlights Original Article
Wells, J C K
Haroun, D
Williams, J E
Nicholls, D
Darch, T
Eaton, S
Fewtrell, M S
Body composition in young female eating-disorder patients with severe weight loss and controls: evidence from the four-component model and evaluation of DXA
title Body composition in young female eating-disorder patients with severe weight loss and controls: evidence from the four-component model and evaluation of DXA
title_full Body composition in young female eating-disorder patients with severe weight loss and controls: evidence from the four-component model and evaluation of DXA
title_fullStr Body composition in young female eating-disorder patients with severe weight loss and controls: evidence from the four-component model and evaluation of DXA
title_full_unstemmed Body composition in young female eating-disorder patients with severe weight loss and controls: evidence from the four-component model and evaluation of DXA
title_short Body composition in young female eating-disorder patients with severe weight loss and controls: evidence from the four-component model and evaluation of DXA
title_sort body composition in young female eating-disorder patients with severe weight loss and controls: evidence from the four-component model and evaluation of dxa
topic Body Composition Highlights Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672328/
https://www.ncbi.nlm.nih.gov/pubmed/26173868
http://dx.doi.org/10.1038/ejcn.2015.111
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